Interaction network and enrichment analysis of genes downregulated in PRKCDBP KD
Canned Analysis
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General Information
AccessionDCA00037543
TitleInteraction network and enrichment analysis of genes downregulated in PRKCDBP KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PRKCDBP KD cells and control cells in the SV589 cell type.
Analysis URLhttp://genemania.org/#/search/human/ATP5B|HSP90B1|MANF|SDF2L1|HSPA8|ACTB|CDC20|SLIRP|ID3|ACTG1|ADM|DNAJB11|EBNA1BP2|IMPDH2|HSPB1|RPS2|C1QBP|CRELD2|AXL|PSMB7|RPS24|SNHG8|SEC61G|SLC35B1|ENO1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorstevann
CREEDS IDgene:1768
Cell TypeSV589
Gene Symbol (human)PRKCDBP
Gene Symbol (mouse)Prkcdbp
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1233858, GSM1233859, GSM1233860, GSM1233861, GSM1233862, GSM1233863, GSM1233864, GSM1233865, GSM1233866, GSM1233867, GSM1233868
Perturbed SamplesGSM1233824, GSM1233825, GSM1233826, GSM1233827, GSM1233828, GSM1233829, GSM1233830, GSM1233831, GSM1233832, GSM1233833, GSM1233834, GSM1233835, GSM1233836, GSM1233837, GSM1233838, GSM1233839, GSM1233840, GSM1233841, GSM1233842, GSM1233843, GSM1233844, GSM
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50982
Gene Expression Omnibus
Cavin-3 Dictates the Balance Between ERK and Akt Signaling
7
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