Interaction network and enrichment analysis of genes downregulated in LEF1 KD
Canned Analysis
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General Information
AccessionDCA00037551
TitleInteraction network and enrichment analysis of genes downregulated in LEF1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between LEF1 KD cells and control cells in the BL2 cell type.
Analysis URLhttp://genemania.org/#/search/human/CYAT1|TUBA1C|TUBB|HSP90AA1|PRKAR2B|ACTB|RPS10|GAPDH|TCL1A|DCAF6|HIST1H4C|CHCHD2|PTGES3|IGLC7|TUBA1B|UBE2S|ATF4|SNRPG|DDX39A|TUBB4B|LOC728026|RRM2|SLC25A5|LAPTM5|RPL32
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1775
Cell TypeBL2
Gene Symbol (human)LEF1
Gene Symbol (mouse)Lef1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1047005, GSM1047007, GSM1047009
Perturbed SamplesGSM1047006, GSM1047008, GSM1047010
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE42637
Gene Expression Omnibus
LEF1 in Burkitt lymphoma
7
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