Interaction network and enrichment analysis of genes upregulated in HDAC1 Drug inhibition (0.5mM VPA for 4 hs)
Canned Analysis
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General Information
AccessionDCA00037588
TitleInteraction network and enrichment analysis of genes upregulated in HDAC1 Drug inhibition (0.5mM VPA for 4 hs)
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between HDAC1 Drug inhibition (0.5mM VPA for 4 hs) cells and control cells in the ES cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/AY036118|Pgk1|Mt2|Malat1|Rpl18a|Gm10925|Wsb1|Rab1|Gm15466|Gm10653|Polr2b|Arl6ip1|Ptma|Hsp90b1|Hat1|Pdia6|Atp5a1|Stt3a|Eef1a1|Hist2h3b|Hist1h3i|Hspa5|Slc2a3|Capns1|Rps2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1803
Cell TypeES cells
Gene Symbol (human)HDAC1
Gene Symbol (mouse)Hdac1
Organismmouse
Perturbation TypeDrug inhibition (0.5mM VPA for 4 hs)
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM590265, GSM590266
Perturbed SamplesGSM590267, GSM590268
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE23957
Gene Expression Omnibus
Gene expression profiles of E14 ESCs treated with low levels of the HDAC inhibitor VPA for 4 hrs
7
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