Interaction network and enrichment analysis of genes downregulated in GSK3B KO
Canned Analysis
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General Information
AccessionDCA00037593
TitleInteraction network and enrichment analysis of genes downregulated in GSK3B KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between GSK3B KO cells and control cells in the ES cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Crabp1|Spp1|Mylpf|Gsta4|LOC100044627|Rpl22l1|Ooep|Gadd45a|Lefty2|Sox2|Gm7325|Gm20767|Uchl4|Erh|Fam208a|Atp5j|Rpl4|AF067061|Tma7|H2afz|Morc1|Uqcrb|Egr1|Klf4|Zfp960
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorFabioAmaral
CREEDS IDgene:1806
Cell TypeES cells
Gene Symbol (human)GSK3B
Gene Symbol (mouse)Gsk3b
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM499768, GSM499769, GSM499770
Perturbed SamplesGSM499762, GSM499763, GSM499764
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE27395
Gene Expression Omnibus
Analysis of Gsk-3-Deficient Embryonic Stem Cells Reveals Large-Scale Alterations in Gene Expression
14
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