Interaction network and enrichment analysis of genes downregulated in TGFB1I1 KD
Canned Analysis
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General Information
AccessionDCA00037635
TitleInteraction network and enrichment analysis of genes downregulated in TGFB1I1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between TGFB1I1 KD cells and control cells in the Immortalized AR positive myofibroblast; 24hr non-specific siRNA, 16hr 10nM DHT treatment replicate 1 cell type.
Analysis URLhttp://genemania.org/#/search/human/SERPINE1|MMP1|HIST1H2BM|HIST1H3I|HIST1H1E|HIST2H2BC|HIST1H3D|HIST1H4C|HIST1H3B|HIST2H4B|HIST2H4A|HIST1H2BH|CKS2|RPL13AP5|HIST1H2BK|HIST2H2AB|HIST2H2AC|FADS1|HIST1H2BF|PGD|ANLN|KPNA2|DCBLD2|HIST2H3D|KPNB1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:1825
Cell TypeImmortalized AR positive myofibroblast; 24hr non-specific siRNA, 16hr 10nM DHT treatment replicate 1
Gene Symbol (human)TGFB1I1
Gene Symbol (mouse)Tgfb1i1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1146794, GSM1146795, GSM1146796
Perturbed SamplesGSM1146800, GSM1146801, GSM1146802
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE47203
Gene Expression Omnibus
Genome-wide expression profiling of Hic-5 knockdown in PshTert-AR human myofibroblasts
14
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