Interaction network and enrichment analysis of genes downregulated in MYC knock-in
Canned Analysis
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General Information
AccessionDCA00037675
TitleInteraction network and enrichment analysis of genes downregulated in MYC knock-in
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MYC knock-in cells and control cells in the germinal center B-cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Laptm5|Hist1h2ap|ND4|Syvn1|Hba-a1|Cd74|Dok3|Hmha1|Plekha2|Tmem200b|Faim3|Fth1|Bcl6|Rnu6|Cd79b|H2-Eb1|Csk|H2-DMb1|H2-Ab1|Rn18s|Ubg|Apobec1|Aldh2|Ubb|Hist1h2af
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:1847
Cell Typegerminal center B-cells
Gene Symbol (human)MYC
Gene Symbol (mouse)Myc
Organismmouse
Perturbation Typeknock-in
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM968811, GSM968813
Perturbed SamplesGSM968810, GSM968812
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE39443
Gene Expression Omnibus
Genome wide analysis of germinal center MYC positive B-cells
7
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