Interaction network and enrichment analysis of genes downregulated in FGFR3 mutant
Canned Analysis
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General Information
AccessionDCA00037689
TitleInteraction network and enrichment analysis of genes downregulated in FGFR3 mutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between FGFR3 mutant cells and control cells in the PC12 cell type.
Analysis URLhttp://genemania.org/#/search/rat/Mt1a|Nnat|Mt2A|Ubc|RGD1559962|COX3|Rps29|ND1|COX1|Rgs4|Gstm1|Dlk1|Actg1|ND2|Adora2a|ND5|CYTB|Syp|COX2|Anapc5|Atp5b|Atp5e|Rt1.aa|LOC360231|Mrfap1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1862
Cell TypePC12
Gene Symbol (human)FGFR3
Gene Symbol (mouse)Fgfr3
Organismrat
Perturbation Typemutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM49962, GSM49963, GSM49964, GSM49965
Perturbed SamplesGSM49958, GSM49959, GSM49960, GSM49961
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE2606
Gene Expression Omnibus
Fibroblast growth factor receptor 3 K650E mutation for type II thanatophoric dysplasia
7
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