Interaction network and enrichment analysis of genes downregulated in TBK1 knockdown
Canned Analysis
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General Information
AccessionDCA00037725
TitleInteraction network and enrichment analysis of genes downregulated in TBK1 knockdown
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between TBK1 knockdown cells and control cells in the lung epithelial cell line cell type.
Analysis URLhttp://genemania.org/#/search/human/RAN|PABPC1|KRT17|SET|RPL6|DDIT4|HMGN1|RPS4X|EEF1A1|ACTB|RPL8|RPL3|RPL12|RLIM|RPS8|RPS3|KRT5|RPLP0P6|RPL11|SLC7A5|YBX1|EEF2|GARS|ARPC1A|RPL13AP5
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1890
Cell Typelung epithelial cell line
Gene Symbol (human)TBK1
Gene Symbol (mouse)Tbk1
Organismhuman
Perturbation Typeknockdown
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM440271, GSM440272, GSM440273, GSM440274, GSM440275, GSM440276
Perturbed SamplesGSM440268, GSM440269, GSM440270
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17643
Gene Expression Omnibus
Profiling of immortalized human lung epithelial cells following oncogenic KRAS expression and TBK1 suppression
21
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