Interaction network and enrichment analysis of genes downregulated in FGFR2 activemutant
Canned Analysis
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General Information
AccessionDCA00037737
TitleInteraction network and enrichment analysis of genes downregulated in FGFR2 activemutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between FGFR2 activemutant cells and control cells in the MMTV-Wnt-1 transgenic mice cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Csn1s1|Csn1s2a|C130090K23Rik|Csn2|Igsf11|Epha5|Gabrp|Slc16a11|2900064B16Rik|Olfr1143|Tcfcp2l1|Mgp|Sostdc1|Chdh|Ly6e|Anxa3|Anxa8|Moxd1|Ildr1|Lao1|Tsx|Mmp3|Aire|Tnfrsf18|Foxd3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1895
Cell TypeMMTV-Wnt-1 transgenic mice
Gene Symbol (human)FGFR2
Gene Symbol (mouse)Fgfr2
Organismmouse
Perturbation Typeactivemutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM447004, GSM447559, GSM447560, GSM447561, GSM447562, GSM447563
Perturbed SamplesGSM447568, GSM447569, GSM447570, GSM447571
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE17916
Gene Expression Omnibus
FGF Receptor and Wnt-1 Signaling Cooperate in Mammary Tumorigenesis
14
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