Interaction network and enrichment analysis of genes upregulated in JAK2 activemutant
Canned Analysis
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General Information
AccessionDCA00037754
TitleInteraction network and enrichment analysis of genes upregulated in JAK2 activemutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between JAK2 activemutant cells and control cells in the LSK cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Hbb-bs|Erdr1|S100a9|Cd74|Egr1|Tmem87a|S100a8|Ctsg|Serpina3g|Lgals1|Camp|Rpl17|Cd48|Cd52|F13a1|Fbp1|Car1|Ngp|Prtn3|Lcn2|Mt2|Tgtp2|Rab44|Gm10482|Sell
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1901
Cell TypeLSK cells
Gene Symbol (human)JAK2
Gene Symbol (mouse)Jak2
Organismmouse
Perturbation Typeactivemutant
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM543489, GSM543490, GSM543491, GSM543492
Perturbed SamplesGSM543493, GSM543494, GSM543495, GSM543496
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE21842
Gene Expression Omnibus
Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells
7
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