Interaction network and enrichment analysis of genes downregulated in ITK defectivemutant
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00037779
TitleInteraction network and enrichment analysis of genes downregulated in ITK defectivemutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ITK defectivemutant cells and control cells in the HVS transformed CD4+ T cells cell type.
Analysis URLhttp://genemania.org/#/search/human/NBPF20|SNORD116-15|S100A10|CCL5|SNORD116-22|GNLY|NBPF19|SNORD116-14|TAGLN2|SNORD116-20|NUDT4|TXNIP|CD55|HLA-B|ID2|FN1|ILF2|HLA-DPA1|TMEM251|CD48|SOCS2|PTMA|CCND2|S100A11|LTA
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1911
Cell TypeHVS transformed CD4+ T cells
Gene Symbol (human)ITK
Gene Symbol (mouse)Itk
Organismhuman
Perturbation Typedefectivemutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM698337, GSM698338, GSM698339
Perturbed SamplesGSM698340, GSM698341, GSM698342
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE28200
Gene Expression Omnibus
Expression data of ITK deficient, HVS transformed CD4+ T cells
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.