Interaction network and enrichment analysis of genes downregulated in CDK8 knockdown
Canned Analysis
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General Information
AccessionDCA00037785
TitleInteraction network and enrichment analysis of genes downregulated in CDK8 knockdown
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CDK8 knockdown cells and control cells in the HeLa S3 cell type.
Analysis URLhttp://genemania.org/#/search/human/DCAF6|COX1|ND2|PLAC8|COX2|LOC728026|RPS18|PTMA|KRT17|CDK4|HSD17B10|HMGN3|FTH1P5|TKT|CHCHD10|WBP5|VDAC2|ATP6|SH3KBP1|HSPB1|RPL11|TMEM147|ASF1B|MCM3|ADSL
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1926
Cell TypeHeLa S3
Gene Symbol (human)CDK8
Gene Symbol (mouse)Cdk8
Organismhuman
Perturbation Typeknockdown
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM796020, GSM796021, GSM796022
Perturbed SamplesGSM796023, GSM796024, GSM796025, GSM796026, GSM796027, GSM796028
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE32108
Gene Expression Omnibus
Knockdown effect of CDK8 or CDK19 in HeLa S3 cell
14
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