Interaction network and enrichment analysis of genes downregulated in MAP2K1 druginhibition
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00037813
TitleInteraction network and enrichment analysis of genes downregulated in MAP2K1 druginhibition
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MAP2K1 druginhibition cells and control cells in the mouse melanoma model cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Timp1|Igfbp3|Spp1|Ccnd1|Mgp|Dusp6|Mmp13|Slc14a1|S100a3|Prl2c4|Areg|Ank|Dusp4|Nefl|Rnf149|Vdac2|Lyz2|Prkg2|Gzme|Lgals3|Klk8|Ccl8|Phlda1|Sgk1|Upp1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1944
Cell Typemouse melanoma model
Gene Symbol (human)MAP2K1
Gene Symbol (mouse)Map2k1
Organismmouse
Perturbation Typedruginhibition
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM982953, GSM982954, GSM982955, GSM982956, GSM982957, GSM982958
Perturbed SamplesGSM982965, GSM982966, GSM982967, GSM982968, GSM982969, GSM982970
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE39984
Gene Expression Omnibus
Comparison of the genetic extinction of NRAS to pharmacological MEK inhibition in an inducible mouse model of melanoma
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.