Interaction network and enrichment analysis of genes downregulated in JAK2 activemutant
Canned Analysis
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General Information
AccessionDCA00037815
TitleInteraction network and enrichment analysis of genes downregulated in JAK2 activemutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between JAK2 activemutant cells and control cells in the myeloproliferative neoplasm propagating stem cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Pf4|Ctse|Rap1b|Tmsb4x|Rpl36a|Rps20|Rps27|Ptma|Hist1h2ad|Ifitm3|Clec2d|Rpl5|Hist2h3b|H3f3b|Hist1h2af|Zyx|Rpl27|Eif3f|Gata2|Rps3a1|H2-T23|Rpl37a|Rps10|Hist1h2an|Lmo2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1949
Cell Typemyeloproliferative neoplasm propagating stem cells
Gene Symbol (human)JAK2
Gene Symbol (mouse)Jak2
Organismmouse
Perturbation Typeactivemutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1094492, GSM1094496, GSM1094500, GSM1094504
Perturbed SamplesGSM1094493, GSM1094497, GSM1094501, GSM1094505
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44961
Gene Expression Omnibus
Depletion of Jak2V617F MPN-propagating stem cells by interferon-alpha in a murine model of polycythemia vera
7
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