Interaction network and enrichment analysis of genes downregulated in ABL1 mutant
Canned Analysis
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General Information
AccessionDCA00037819
TitleInteraction network and enrichment analysis of genes downregulated in ABL1 mutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ABL1 mutant cells and control cells in the cord blood cells cell type.
Analysis URLhttp://genemania.org/#/search/human/SRGN|ELANE|DEFA1|MPO|S100A9|CST3|HLA-DRA|S100A8|LYZ|DEFA3|ITGB2|TMSB10|CTSG|ARHGDIB|DEFA1B|HLA-DPA1|CD14|PRTN3|SPP1|NPC2|RNASE2|VIM|CXCL8|DEFA4|FCN1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1950
Cell Typecord blood cells
Gene Symbol (human)ABL1
Gene Symbol (mouse)Abl1
Organismhuman
Perturbation Typemutant
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1104493, GSM1104494, GSM1104495, GSM1104496
Perturbed SamplesGSM1104497, GSM1104498, GSM1104499, GSM1104500
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45452
Gene Expression Omnibus
BCR-ABL1 and a dominant negative isoform of Ikaros cooperate to induce human acute myeloid leukemia
7
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