Interaction network and enrichment analysis of genes downregulated in BRAF overexpression
Canned Analysis
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General Information
AccessionDCA00037821
TitleInteraction network and enrichment analysis of genes downregulated in BRAF overexpression
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between BRAF overexpression cells and control cells in the melanocytes cell type.
Analysis URLhttp://genemania.org/#/search/human/TYRP1|MLANA|PMEL|TRIM63|SERPINF1|OCA2|CAPN3|LOC101929450|FAM69C|CKS2|H2AFZ|KIT|DCT|APOLD1|CTSK|C6orf48|LINC00520|GPR143|VAT1|SDCBP|SCD|AEBP1|PROS1|CDR1|RASSF3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1951
Cell Typemelanocytes
Gene Symbol (human)BRAF
Gene Symbol (mouse)Braf
Organismhuman
Perturbation Typeoverexpression
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1138533, GSM1138534, GSM1138535
Perturbed SamplesGSM1138536, GSM1138537, GSM1138538
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE46801
Gene Expression Omnibus
Expression data from Control, Uninfected and BRAF infected cells
7
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