Interaction network and enrichment analysis of genes downregulated in SYK knockdown
Canned Analysis
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General Information
AccessionDCA00037837
TitleInteraction network and enrichment analysis of genes downregulated in SYK knockdown
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SYK knockdown cells and control cells in the U937 cell type.
Analysis URLhttp://genemania.org/#/search/human/MYC|CTSG|GLO1|PTMA|NUCB2|TUBA1B|ARPC2|HMGB1|TUBB|NXF3|SNRPD2|LOC643287|IFITM2|PTDSS1|IARS|H2AFZ|CST7|CKS1B|YARS|HMGB2|MIF|GOLGA8EP|HAT1|ZNF706|LAMP5
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1959
Cell TypeU937
Gene Symbol (human)SYK
Gene Symbol (mouse)Syk
Organismhuman
Perturbation Typeknockdown
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1306638, GSM1306639, GSM1306640
Perturbed SamplesGSM1306641, GSM1306642, GSM1306643, GSM1306644
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54065
Gene Expression Omnibus
SYK Is a Critical Regulator of FLT3 In Acute Myeloid Leukemia
21
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