Interaction network and enrichment analysis of genes upregulated in RAF1 activemutant
Canned Analysis
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General Information
AccessionDCA00037864
TitleInteraction network and enrichment analysis of genes upregulated in RAF1 activemutant
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between RAF1 activemutant cells and control cells in the HUVEC cell type.
Analysis URLhttp://genemania.org/#/search/human/TIMP1|SOX18|TMEM158|CD93|SRPX|CLDN5|GNG11|GSTO1|SLC20A1|ARHGDIB|CTSB|CIB1|TUBB3|MMP10|TOX2|PRSS3|OAZ1|PNP|ATP5B|PRKCDBP|MGST2|OAF|CCND1|LGALS1|BCAP31
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1981
Cell TypeHUVEC
Gene Symbol (human)RAF1
Gene Symbol (mouse)Raf1
Organismhuman
Perturbation Typeactivemutant
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1054054, GSM1054056, GSM1054058, GSM1054060
Perturbed SamplesGSM1054055, GSM1054057, GSM1054062, GSM1054064
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE42964
Gene Expression Omnibus
Endothelial Raf1 activation regulates arterial morphogenesis
14
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