Interaction network and enrichment analysis of genes downregulated in BRD4 druginhibition
Canned Analysis
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General Information
AccessionDCA00037871
TitleInteraction network and enrichment analysis of genes downregulated in BRD4 druginhibition
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between BRD4 druginhibition cells and control cells in the spindle cell malignant peripheral nerve sheath tumor cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ifitm3|Crabp1|Ly6a|Il1rl1|Mgp|Ccl2|Arhgdib|Ly6c2|Bgn|Col6a3|Gm3601|Ank|Pcolce|Ptpla|Pcbp1|Errfi1|Rbp1|Tmem176b|Ifitm2|Gm19420|Hsp90b1|Cav1|Tpm4|Dap|Ccnd1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1986
Cell Typespindle cell malignant peripheral nerve sheath tumor cells
Gene Symbol (human)BRD4
Organismmouse
Perturbation Typedruginhibition
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1231304, GSM1231305, GSM1231306
Perturbed SamplesGSM1231307, GSM1231308, GSM1231309
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50865
Gene Expression Omnibus
Expression Data For BRD4 Inhibition
14
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