Interaction network and enrichment analysis of genes downregulated in CDK4 knockdown
Canned Analysis
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General Information
AccessionDCA00037873
TitleInteraction network and enrichment analysis of genes downregulated in CDK4 knockdown
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CDK4 knockdown cells and control cells in the IMR-32 cell type.
Analysis URLhttp://genemania.org/#/search/human/RPS2|LGALS1|CDK4|PTMA|IL13RA2|MIR1244-2|ODC1|NPM1|RPS20|HIST1H4C|PTTG1|RRM2|CKS1B|SNRNP25|RPA3|PCNA|PRC1|C14orf2|MAD2L1|UBE2T|H2AFZ|CENPW|TUBB|ENOPH1|TUBB2A
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:1987
Cell TypeIMR-32
Gene Symbol (human)CDK4
Gene Symbol (mouse)Cdk4
Organismhuman
Perturbation Typeknockdown
None{u'vals': [0.0402710304397, 0.0388046266098, 0.0372196339108, 0.0371656527783, -0.0364691794925, 0.0360509234586, 0.0355038835249, 0.0348491400967, 0.0342044513455, 0.0326396519607, 0.0325756125895, 0.0317195103794, -0.0314642399633, -0.0313235995535, 0.0
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM220189, GSM220205, GSM220208
Perturbed SamplesGSM220191, GSM220207, GSM220210
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE8866
Gene Expression Omnibus
The undifferentiated phenotype in neuroblastoma depends on Cyclin D1 and CDK4 activity
14
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