Interaction network and enrichment analysis of genes downregulated in MOK knockout
Canned Analysis
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General Information
AccessionDCA00037911
TitleInteraction network and enrichment analysis of genes downregulated in MOK knockout
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MOK knockout cells and control cells in the aorta, nondiabetic, ApoE KO cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Hbb-bs|Myl7|Hba-a2|Mup19|Eln|Actc1|Tcap|Col3a1|Clu|Actb|Dbp|LOC100503721|Cfd|Chchd2|Gm4076|Car3|Postn|Col1a1|Tnni3|Igkv6-23|Fstl1|Serpine1|Calr|Ctgf|Rpl39-ps
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2011
Cell Typeaorta, nondiabetic, ApoE KO
Gene Symbol (human)MOK
Gene Symbol (mouse)Mok
Organismmouse
Perturbation Typeknockout
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM390127, GSM390128, GSM390129, GSM390289
Perturbed SamplesGSM392146, GSM392156, GSM392158
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15729
Gene Expression Omnibus
Receptor for AGE (RAGE) deletion effect on ApoE null mice: aorta
14
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