Interaction network and enrichment analysis of genes downregulated in TRIM28 knockout
Canned Analysis
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General Information
AccessionDCA00037937
TitleInteraction network and enrichment analysis of genes downregulated in TRIM28 knockout
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between TRIM28 knockout cells and control cells in the Treg cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Gm14025|Rps16|Rps23|Rpl12|Nr4a1|Rpl18a|Ddit4|Cd5|Rps8|Gm10406|Rpl8|Dtx1|Rps14|Rps5|Gm13777|Rps3a1|Rpl27|Rplp0|Rps11|Cd97|Rps3|Hist1h2ao|Zfp36l1|Gpr83|Pagr1a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2032
Cell TypeTreg cells
Gene Symbol (human)TRIM28
Gene Symbol (mouse)Trim28
Organismmouse
Perturbation Typeknockout
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM798473, GSM798474, GSM798475, GSM798476
Perturbed SamplesGSM798477, GSM798478, GSM798479, GSM798480
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE32224
Gene Expression Omnibus
Comparison of gene expression in Wild type and T cell-specific conditional Trim28 KO in TCR stimulated and un-stimulated naive CD4 positive and T regu...
21
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