Interaction network and enrichment analysis of genes upregulated in WEE1 druginhibition
Canned Analysis
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General Information
AccessionDCA00037990
TitleInteraction network and enrichment analysis of genes upregulated in WEE1 druginhibition
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between WEE1 druginhibition cells and control cells in the PC3 cell type.
Analysis URLhttp://genemania.org/#/search/human/TUBA1A|ATF4|TMSB10|RPL36A|RPL12|RPL4|RPL3|EEF2|RPS2|RPS29|RPL13A|TYRP1|RPLP0P6|RPL8|RPS10|GARS|RPL9|RPLP0|TUBB2A|TPT1|RPS8|RPS20|RPS4X|SNHG6|LGALS1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2064
Cell TypePC3
Gene Symbol (human)WEE1
Gene Symbol (mouse)Wee1
Organismhuman
Perturbation Typedruginhibition
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM953063, GSM953067, GSM953071
Perturbed SamplesGSM953064, GSM953068, GSM953072
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE38972
Gene Expression Omnibus
Wee1 Inhibition sensitizes prostate cancer cells to Hsp90 inhibitor to activate the intrinsic apoptotic pathway
7
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