Interaction network and enrichment analysis of genes upregulated in JAK2 knockdown
Canned Analysis
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General Information
AccessionDCA00037992
TitleInteraction network and enrichment analysis of genes upregulated in JAK2 knockdown
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between JAK2 knockdown cells and control cells in the HEL cell type.
Analysis URLhttp://genemania.org/#/search/human/HBG2|ACTG1|ALDOA|HBA1|ACTB|RPL8|HBA2|COX6B1|RPSA|TUBB|CHCHD2|GAPDH|VIM|GPI|ARF1|TKT|PGAM1|TAGLN2|FDFT1|UCP2|RPL3|EIF6|GYPC|ANP32B|SH3BGRL3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAndrew
CREEDS IDgene:2067
Cell TypeHEL
Gene Symbol (human)JAK2
Gene Symbol (mouse)Jak2
Organismhuman
Perturbation Typeknockdown
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1320628, GSM1320629, GSM1320630, GSM1320637, GSM1320638, GSM1320639
Perturbed SamplesGSM1320631, GSM1320632, GSM1320633, GSM1320634, GSM1320635, GSM1320636
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE54645
Gene Expression Omnibus
Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]
7
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