Interaction network and enrichment analysis of genes downregulated in HSF1 KD
Canned Analysis
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General Information
AccessionDCA00038031
TitleInteraction network and enrichment analysis of genes downregulated in HSF1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HSF1 KD cells and control cells in the RKO_colon_carcinoma cell type.
Analysis URLhttp://genemania.org/#/search/human/HSPH1|PSMA4|HSP90AA1|AHSA1|STC1|HSP90AB1|CCT5|HIST1H2AC|ITGB1|TCP1|STIP1|HIST2H2AC|FUS|CKS2|MYL5|TUBA1C|TM4SF1|SMU1|HSPA4L|PPAT|NAA50|PRDX1|SOD1|CDC6|ANXA5
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorKevin
CREEDS IDgene:2142
Cell TypeRKO_colon_carcinoma
Gene Symbol (human)HSF1
Gene Symbol (mouse)Hsf1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM320083, GSM320084, GSM320085
Perturbed SamplesGSM320165, GSM320166, GSM320167
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE12762
Gene Expression Omnibus
Effect of 4-Hydroxynonenal on gene expression. Comparison of HSF1-siRNA silenced vs control cells
7
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