Interaction network and enrichment analysis of genes upregulated in CCND1 KD
Canned Analysis
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General Information
AccessionDCA00038114
TitleInteraction network and enrichment analysis of genes upregulated in CCND1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between CCND1 KD cells and control cells in the MCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Estradiol treated cells were maintained for a further 24 hrs and then processed. cell type.
Analysis URLhttp://genemania.org/#/search/human/KLRK1|ACTG2|RPS6KA6|ACTA2|PCDHB4|SYCP2L|SAMD9L|SNAI2|CLDN1|ANKRD1|DIO2|CCDC108|IFIT2|GBP3|TGFB2|CMPK2|HCP5|NPY1R|USP17L9P|SULF1|BTN3A2|RSAD2|SAMD9|HLA-DRA|APBB1IP
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2207
Cell TypeMCF7 cells were transfected with control or cyclin D1 siRNA. Cells were maintained for 48hrs to allow for efficient knock-down. Estradiol treated cells were maintained for a further 24 hrs and then processed.
Gene Symbol (human)CCND1
Gene Symbol (mouse)Ccnd1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1191288, GSM1191289
Perturbed SamplesGSM1191292, GSM1191293
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE48989
Gene Expression Omnibus
Cyclin D1 determines estrogen dependent signaling in human breast cancer cell line MCF7
14
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