Interaction network and enrichment analysis of genes downregulated in LAMC2 KD
Canned Analysis
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General Information
AccessionDCA00038121
TitleInteraction network and enrichment analysis of genes downregulated in LAMC2 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between LAMC2 KD cells and control cells in the HTH83 Anaplastic thyroid carcinoma cell type.
Analysis URLhttp://genemania.org/#/search/human/KRT6A|IL1B|CLDN1|PFN1|ALDH1A3|H3F3A|RPL21|HSPA8|KRT17|MT1X|GNG11|RPS27A|CCND1|ACTG1|FGFBP1|MDH2|MT2A|ZNF674|S100A10|PSMB1|MT1A|HNRNPD|SLIRP|MFSD10|TMSB10
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatormaroulisv
CREEDS IDgene:2208
Cell TypeHTH83 Anaplastic thyroid carcinoma
Gene Symbol (human)LAMC2
Gene Symbol (mouse)Lamc2
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1228812, GSM1228813, GSM1228814
Perturbed SamplesGSM1228815, GSM1228816, GSM1228817
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE50767
Gene Expression Omnibus
Anaplastic thyroid carcinoma cell lines (HTH83 and TL3) infected with LAMC2 shRNA
14
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