Interaction network and enrichment analysis of genes downregulated in EGR3 KD
Canned Analysis
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General Information
AccessionDCA00038165
TitleInteraction network and enrichment analysis of genes downregulated in EGR3 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between EGR3 KD cells and control cells in the Human prostate cancer cells M12 cell type.
Analysis URLhttp://genemania.org/#/search/human/PPIB|KRT18|PSMA1|SRP14|TALDO1|ACAT2|CLIC1|LDHB|RPL4|C3|UBA52|TMEM126A|CCT2|LDHA|HIST1H4C|RPS13|PSMB3|PSMA4|PSMD14|CXCL1|NOP10|PTTG1IP|MORF4L1|NSA2|PSMB6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
CREEDS IDgene:2231
Cell TypeHuman prostate cancer cells M12
Gene Symbol (human)EGR3
Gene Symbol (mouse)Egr3
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1259796, GSM1259797
Perturbed SamplesGSM1259794, GSM1259795
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE52108
Gene Expression Omnibus
Gene expression signature of EGR3 silencing in M12 human prostate cancer cells
14
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