Interaction network and enrichment analysis of genes downregulated in HIF1A KD
Canned Analysis
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General Information
AccessionDCA00038171
TitleInteraction network and enrichment analysis of genes downregulated in HIF1A KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HIF1A KD cells and control cells in the Heptaocellular carcinoma cell line HepG2 cells were infected with S. aureus 8325-4 (MOI: 20) for four hours (5 % CO2, 96 % humidity and 37 °C) cell type.
Analysis URLhttp://genemania.org/#/search/human/SLC2A3|GAPDH|LDHA|HIST1H2BM|HIF1A|ENO1|DDIT4|ITIH2|SNORD33|UBC|SLC2A1|BNIP3|HIST1H1E|HK2|NCOA4|ABCC2|GLUD2|P4HA1|PGK1|TUBB|GDI2|SLC5A6|RNA18S5|PKM|PDK1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2235
Cell TypeHeptaocellular carcinoma cell line HepG2 cells were infected with S. aureus 8325-4 (MOI: 20) for four hours (5 % CO2, 96 % humidity and 37 °C)
Gene Symbol (human)HIF1A
Gene Symbol (mouse)Hif1a
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1094268, GSM1094269, GSM1094270
Perturbed SamplesGSM1094262, GSM1094263, GSM1094264
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE44943
Gene Expression Omnibus
HIF-1 dependent gene expression upon S. aureus infection
14
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