Interaction network and enrichment analysis of genes downregulated in HIRA KD
Canned Analysis
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General Information
AccessionDCA00038177
TitleInteraction network and enrichment analysis of genes downregulated in HIRA KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between HIRA KD cells and control cells in the cell type: HeLa cell type.
Analysis URLhttp://genemania.org/#/search/human/ANP32B|PSME2|NPM1|LOC728026|MRPS23|C1QBP|HSP90AA1|NSA2|SSRP1|TXN|HSP90AB1|TMA7|FTH1|SSB|DDIT4|CBWD1|ASUN|PTMA|EEF1A1P9|HIST1H4E|SOD1|DKC1|TRIM16|SLC7A5|EBNA1BP2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2238
Cell Typecell type: HeLa
Gene Symbol (human)HIRA
Gene Symbol (mouse)Hira
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1101720, GSM1101721, GSM1101722
Perturbed SamplesGSM1101717, GSM1101718, GSM1101719
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE45295
Gene Expression Omnibus
Expression data from Control, HIRA and CABIN1 knockdown cells
14
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