Interaction network and enrichment analysis of genes downregulated in KRAS Knock-down, shRNA
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00038195
TitleInteraction network and enrichment analysis of genes downregulated in KRAS Knock-down, shRNA
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between KRAS Knock-down, shRNA cells and control cells in the LKR13 cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Spp1|Prl2c4|Lgals1|S100a4|F2r|Fos|Ier3|Klra18|Hmga1-rs1|Pcna|Areg|Npm1|Egr1|Prl|Snrpe|Apoc2|Gm6793|Cks1b|Serpinb6a|Mt2|Psat1|Asns|Ube2c|Rpl36a|Cxcl1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:2247
Cell TypeLKR13
Gene Symbol (human)KRAS
Gene Symbol (mouse)Kras
Organismmouse
Perturbation TypeKnock-down, shRNA
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM384915, GSM384916, GSM384917, GSM384918
Perturbed SamplesGSM384911, GSM384912, GSM384919, GSM384920
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE15326
Gene Expression Omnibus
LKR13-Kras-WT1-KO
14
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.