Interaction network and enrichment analysis of genes downregulated in PTEN PTEN F341V
Canned Analysis
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General Information
AccessionDCA00038203
TitleInteraction network and enrichment analysis of genes downregulated in PTEN PTEN F341V
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PTEN PTEN F341V cells and control cells in the mammary duct epithelial cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Hspa1b|Hspa1a|Dusp1|Wfdc17|BC094435|Hal|Klf4|Rpl39-ps|Rps12|Ccl6|Cd74|Ptma|Cxcl2|Klf2|Fosb|Cd209d|Cd163|Lilrb4|Actr3|LOC100503721|Dek|Cd209b|Rps27rt|Ifitm3|Gm19579
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:2252
Cell Typemammary duct epithelial cells
Gene Symbol (human)PTEN
Gene Symbol (mouse)Pten
Organismmouse
Perturbation TypePTEN F341V
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1568335, GSM1568336, GSM1568337, GSM1568338
Perturbed SamplesGSM1568339, GSM1568340, GSM1568341, GSM1568342
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE64303
Gene Expression Omnibus
Expression Data from Pten mutant epithelial cells
21
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