Interaction network and enrichment analysis of genes downregulated in LMNA HGPS single-point mutation
Canned Analysis
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General Information
AccessionDCA00038209
TitleInteraction network and enrichment analysis of genes downregulated in LMNA HGPS single-point mutation
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between LMNA HGPS single-point mutation cells and control cells in the fibroblasts (bj-fib_2 and HGPS-fib_2) cell type.
Analysis URLhttp://genemania.org/#/search/human/MMP1|MMP3|KRT18|SYPL2|ALDH1A1|IFITM2|IFITM1|STMN2|IFITM3|C8orf4|ASS1|SLC38A11|PCOLCE|EEF1D|RGS2|WNT5A|SLIT2|TNS3|TNFRSF11B|UCHL1|COL6A3|AEBP1|GPRC5A|CAV1|PSME1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2257
Cell Typefibroblasts (bj-fib_2 and HGPS-fib_2)
Gene Symbol (human)LMNA
Gene Symbol (mouse)Lmna
Organismhuman
Perturbation TypeHGPS single-point mutation
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM603015, GSM603043
Perturbed SamplesGSM603044, GSM603045
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE24487
Gene Expression Omnibus
Induced pluripotent stem cell-based accelerated aging model
14
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