Interaction network and enrichment analysis of genes downregulated in PPARGC1A KO
Canned Analysis
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General Information
AccessionDCA00038247
TitleInteraction network and enrichment analysis of genes downregulated in PPARGC1A KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PPARGC1A KO cells and control cells in the Brown fat cell cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Cdkn1c|Rbp4|H2-L|B2m|H2-K1|Actg1|Pmp22|Pcolce|Egln3|H1f0|Pltp|Phlda3|Col6a3|Sncg|Psmb9|Fabp5|Anxa2|Tuba1a|Srsf5|Apol6|Tmsb4x|Gm3244|Wdr6|Manf|Arxes1
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcadimo
CREEDS IDgene:2281
Cell TypeBrown fat cell
Gene Symbol (human)PPARGC1A
Gene Symbol (mouse)Ppargc1a
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM113409, GSM113411
Perturbed SamplesGSM113461, GSM113462
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE5042
Gene Expression Omnibus
Brown fat cell response to PGC-1alpha and PGC-1beta deficiency
14
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