Interaction network and enrichment analysis of genes downregulated in MN1 OE
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00038275
TitleInteraction network and enrichment analysis of genes downregulated in MN1 OE
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between MN1 OE cells and control cells in the 72 hours after transduction with MSCV-IRES-GFP, gfp positive bone marrow cells were sorted and RNA isolated from FVB 129 mice cell type.
Analysis URLhttp://genemania.org/#/search/mouse/AY036118|Gzmb|Cxcl10|Elane|Prg2|Ccl3|Akr1c18|Lcn2|Igfbp5|Hist1h2ao|Ngp|Irg1|Hist1h2bn|S100a8|Pglyrp1|Gm5483|Prtn3|Mpo|Hist2h2aa2|Cxcr4|S100a9|Ifitm1|BC018473|Hist1h2br|Tgm2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2305
Cell Type72 hours after transduction with MSCV-IRES-GFP, gfp positive bone marrow cells were sorted and RNA isolated from FVB 129 mice
Gene Symbol (human)MN1
Gene Symbol (mouse)Mn1
Organismmouse
Perturbation TypeOE
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM333160, GSM333161, GSM333162
Perturbed SamplesGSM333157, GSM333158, GSM333159
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE13189
Gene Expression Omnibus
Functional collaboration of the meningioma 1 (MN1) oncogene with MLL-fusions in pediatric leukemia
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.