Interaction network and enrichment analysis of genes downregulated in KLF5 KO
Canned Analysis
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General Information
AccessionDCA00038289
TitleInteraction network and enrichment analysis of genes downregulated in KLF5 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between KLF5 KO cells and control cells in the dorsal prostate, PTEN-null background cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Gsdmc2|Cyp2f2|Cbr2|Reg3g|Pglyrp1|Sprr2a2|Lrrc26|Wfdc2|Krt4|Sprr2a1|Csprs|Muc19|Tff3|Upk1b|Tspan8|Gm12888|Gm7609|Tc2n|Ltf|Idh1|Slc39a4|Lypd8|Agr2|Anxa3|Elf3
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:2318
Cell Typedorsal prostate, PTEN-null background
Gene Symbol (human)KLF5
Gene Symbol (mouse)Klf5
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1418653, GSM1418654, GSM1418655, GSM1418656
Perturbed SamplesGSM1418657, GSM1418658, GSM1418659, GSM1418660
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE58719
Gene Expression Omnibus
Expression data from conditional Klf5 knockout Pten-null mouse prostates
7
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