Interaction network and enrichment analysis of genes downregulated in ESR1 KD
Canned Analysis
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General Information
AccessionDCA00038301
TitleInteraction network and enrichment analysis of genes downregulated in ESR1 KD
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between ESR1 KD cells and control cells in the MCF7 cell type.
Analysis URLhttp://genemania.org/#/search/human/KRT18|TPD52L1|AGR3|SLC38A2|NME1|CA2|GLA|SLC6A14|PRSS23|EEF1A1P9|RAN|SLC9A3R1|RPSA|HSP90AB1|CCT2|HSPA8|DKC1|TMEM183B|NBPF10|MTHFD1|NPM1|KARS|BZW2|C1QBP|NPY1R
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorOliFucMuc
CREEDS IDgene:2326
Cell TypeMCF7
Gene Symbol (human)ESR1
Gene Symbol (mouse)Esr1
Organismhuman
Perturbation TypeKD
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM928442, GSM928443, GSM928444
Perturbed SamplesGSM928445, GSM928446, GSM928447
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE37820
Gene Expression Omnibus
Gene expression profile in MCF7 breast cancer cells after siRNA knock down of estrogen receptor alpha (ESR1)
7
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