Interaction network and enrichment analysis of genes upregulated in TLR4 KO
Canned Analysis
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General Information
AccessionDCA00038384
TitleInteraction network and enrichment analysis of genes upregulated in TLR4 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between TLR4 KO cells and control cells in the primary mouse microglia cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Rny3|Itgax|Plau|Cst3|Tyrobp|Pmp22|Fn1|Tmem189|Pea15a|Atp6v0a1|Rpl28|Cdk18|Rpl10a|Adamts1|AY036118|Rpl18a|Tln1|Tspan7|Erdr1|Gm6251|Rps8|Rpl10|Lgals1|Rps4x|Gltp
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatornbongio
CREEDS IDgene:2372
Cell Typeprimary mouse microglia
Gene Symbol (human)TLR4
Gene Symbol (mouse)Tlr4
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM462515, GSM462516, GSM462517
Perturbed SamplesGSM462512, GSM462513, GSM462514
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE18602
Gene Expression Omnibus
Microglia in ischemic brain injury
7
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