Interaction network and enrichment analysis of genes downregulated in SMARCA5 KO
Canned Analysis
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General Information
AccessionDCA00038395
TitleInteraction network and enrichment analysis of genes downregulated in SMARCA5 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SMARCA5 KO cells and control cells in the P1 mouse eyeball genotype/variation: Snf2h lens-conditional knockout strain: C57BL/6 age: newborn cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Crygs|Hbb-bs|Crygn|Crygf|Cryba4|2700079J08Rik|Crybb1|Crygc|Hba-a2|Rps26|Cryga|Cryba1|Col4a2|Cd24a|Capn3|Cryba2|F630007L15Rik|Crygb|Crygd|Rpl17-ps9|Bfsp1|Ndufa1|Gm4354|Fam46c|Rpl27a
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2382
Cell TypeP1 mouse eyeball genotype/variation: Snf2h lens-conditional knockout strain: C57BL/6 age: newborn
Gene Symbol (human)SMARCA5
Gene Symbol (mouse)Smarca5
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1020078, GSM1020079, GSM1020080, GSM1020081
Perturbed SamplesGSM1020082, GSM1020083, GSM1020084, GSM1020085
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41608
Gene Expression Omnibus
Chromatin Remodeling Enzyme Smarca5/Snf2h Regulates Cell Cycle Exit, Differentiation of the Lens Epithelium, and Denucleation of Lens Fiber Cells
14
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