Interaction network and enrichment analysis of genes downregulated in SMARCA4 KO
Canned Analysis
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General Information
AccessionDCA00038397
TitleInteraction network and enrichment analysis of genes downregulated in SMARCA4 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SMARCA4 KO cells and control cells in the P1 mouse eyeball Brg1 lens-conditional knockout genotype/variation: Brg1_cKO1 strain: mixed background (Gebuhr TC, Kovalev GI, Bultman S, Godfrey V, Su L, Magnuson T. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med. 2003 Dec 15;198(12):1937-49.) age: P1 cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Crygd|Cryba2|Crybb3|Crygc|Crybb1|Cryba1|Crygb|Crygs|Cryaa|Cryga|Cryba4|Crygf|Pla2g16|Krt15|Crygn|Bfsp1|Wfdc18|Nupr1|Rps2-ps6|Fabp5|Hist1h2ao|Cd24a|Mip|Krt19|F630007L15Rik
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curator
CREEDS ID
Cell Type
Gene Symbol (human)
Gene Symbol (mouse)
Organism
Perturbation Type
Characteristic Direction parameters
Gene Set
Gene Set Size
Control Samples
Perturbed Samples
Tools used in the analysis

Keyword
Dataset Accession

GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis

Keyword
Tool Name

GSE41608
Chromatin Remodeling Enzyme Smarca5/Snf2h Regulates Cell Cycle Exit, Differentiation of the Lens Epithelium, and Denucleation of Lens Fiber Cells
14
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