Interaction network and enrichment analysis of genes downregulated in DES KO
Canned Analysis
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General Information
AccessionDCA00038403
TitleInteraction network and enrichment analysis of genes downregulated in DES KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between DES KO cells and control cells in the genetic background: 129/SVE tissue: tibialis anterior age: 12-14 mo (aged) treatment: 50 eccentric contractions 12 hours cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Hspa1a|Flnc|Car3|Hspa1b|Hsp90aa1|Gm3150|Ankrd1|Dnajb1|Hbegf|Slc38a2|Asb5|Dnaja1|Actb|Actc1|Fos|Atf3|Rnf115|Egr1|Ifrd1|Rrad|Hspa5|Xirp1|Pdk4|Hspa8|Hba-a2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2388
Cell Typegenetic background: 129/SVE tissue: tibialis anterior age: 12-14 mo (aged) treatment: 50 eccentric contractions 12 hours
Gene Symbol (human)DES
Gene Symbol (mouse)Des
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM1015527, GSM1015528, GSM1015529, GSM1015530, GSM1015531
Perturbed SamplesGSM1015537, GSM1015538, GSM1015539, GSM1015540
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE41363
Gene Expression Omnibus
Role of the Cytoskeleton in muscle transcriptional response to altered use
14
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