Interaction network and enrichment analysis of genes downregulated in CTLA4 KO
Canned Analysis
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General Information
AccessionDCA00038419
TitleInteraction network and enrichment analysis of genes downregulated in CTLA4 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CTLA4 KO cells and control cells in the T cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction. cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ctla4|Ms4a4c|Gpr18|Folr4|Mndal|Ephx1|Nrn1|Stx16|Cd3g|Smc4|Smpdl3a|Ifih1|Itm2c|Bach2|Pisd|Gvin1|Cd96|Gimap8|Itm2a|Nrp1|H2-Q7|Ms4a6b|Cd200|Rgs10|Btla
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2400
Cell TypeT cells from 5C.C7 RAG2-/- CD45.1 and 5C.C7 RAG2-/- CD45.1 CTLA-4-/- mice were activated by immunization with MCC peptide and LPS and after 4 days sorted for RNA extraction.
Gene Symbol (human)CTLA4
Gene Symbol (mouse)Ctla4
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM921632, GSM921633, GSM921634
Perturbed SamplesGSM921635, GSM921636, GSM921637
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE37563
Gene Expression Omnibus
In vivo gene expression data from wild type and CTLA-4 KO 5C.C7 T cells
7
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