Interaction network and enrichment analysis of genes upregulated in PRMT5 KO
Canned Analysis
FAIR Metrics
0 evaluations
General Information
AccessionDCA00038424
TitleInteraction network and enrichment analysis of genes upregulated in PRMT5 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most upregulated genes identified by applying the Characteristic Direction method comparing gene expression between PRMT5 KO cells and control cells in the Neural stem/ progenitor cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Atp5g3|Tuba1a|Tmsb4x|Fth1|Gm1821|Ubb|Reln|Rps27l|Mt1|Atpif1|Ccnd1|Erdr1|Ccnd2|Higd2a|Prnp|Stmn2|Vim|Nrep|Ndufa4|Gap43|Ckb|Wbp2|Atp6v1e1|Cox8a|Mrps6
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorRuta
CREEDS IDgene:2403
Cell TypeNeural stem/ progenitor cells
Gene Symbol (human)PRMT5
Gene Symbol (mouse)Prmt5
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setupregulated
Gene Set Size50
Control SamplesGSM1100469, GSM1100470, GSM1100471, GSM1100472
Perturbed SamplesGSM1100473, GSM1100474, GSM1100475, GSM1100476
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE45269
Gene Expression Omnibus
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery (BeadCh...
7
FAIR Evaluation
Sorry, you must be signed in to evaluate this object.