Interaction network and enrichment analysis of genes downregulated in CYP27B1 KO
Canned Analysis
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General Information
AccessionDCA00038425
TitleInteraction network and enrichment analysis of genes downregulated in CYP27B1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between CYP27B1 KO cells and control cells in the genotype/variation: Cyp27b1 flox/flox;Cre+ OR Cre- tissue: breast tumor genetic background: FVB cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Timp1|Lox|Bgn|Thbs2|Zyx|Col4a1|Col1a1|Lgals1|Ctgf|Tuba1b|Col5a1|Emp1|Pdpn|Col4a2|Mmp2|Actg2|Csrp2|F2r|Ly6a|Pdlim1|Ddah1|Inhba|Cstb|Sif1|Ccl7
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorgszeto
CREEDS IDgene:2404
Cell Typegenotype/variation: Cyp27b1 flox/flox;Cre+ OR Cre- tissue: breast tumor genetic background: FVB
Gene Symbol (human)CYP27B1
Gene Symbol (mouse)Cyp27b1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM992462, GSM992463, GSM992464
Perturbed SamplesGSM992465, GSM992466, GSM992467
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE40375
Gene Expression Omnibus
Lack of local vitamin D synthesis accelerates breast cancer development after Cyp27B1 gene ablation in mammary epithelium
7
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