Interaction network and enrichment analysis of genes downregulated in FMR1 KO
Canned Analysis
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General Information
AccessionDCA00038461
TitleInteraction network and enrichment analysis of genes downregulated in FMR1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between FMR1 KO cells and control cells in the blood cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Tubb1|Treml1|Gm5069|Nkg7|Sptb|Ube2o|Cdr2|Sprr2a2|Gm3579|Mtmr3|Bsdc1|Fam117a|Depdc1b|Gm15800|Specc1|Acsl1|Nefm|Myl12b|Blvrb|Ube2s|Lyz2|Flna|Hist1h1c|Myl9|Olfr151
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDgene:2419
Cell Typeblood
Gene Symbol (human)FMR1
Gene Symbol (mouse)Fmr1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM998370, GSM998371, GSM998372, GSM998373, GSM998374
Perturbed SamplesGSM998360, GSM998361, GSM998362, GSM998363, GSM998364
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE40630
Gene Expression Omnibus
Divergent dysregulation of gene expression in Fmr1 and Tsc2 knockout mouse models of autism spectrum disorders
21
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