Interaction network and enrichment analysis of genes downregulated in THRB d337T mutation - dominant negative
Canned Analysis
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General Information
AccessionDCA00038487
TitleInteraction network and enrichment analysis of genes downregulated in THRB d337T mutation - dominant negative
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between THRB d337T mutation - dominant negative cells and control cells in the heart cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Acta1|E430024C06Rik|Ddit4|Hspb6|Myl1|Ndufs2|Fhl2|Gm3150|Nrap|Ccrn4l|Hist1h2br|Serpine1|H2-L|Amd1|Aqp1|Txnip|Srl|Ppif|Myl2|B2m|Myh6|Vegfb|Slc2a4|Dgat2|Hk2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2435
Cell Typeheart
Gene Symbol (human)THRB
Gene Symbol (mouse)Thrb
Organismmouse
Perturbation Typed337T mutation - dominant negative
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM67362, GSM67363, GSM67364, GSM67365, GSM67366, GSM67367, GSM67368
Perturbed SamplesGSM67369, GSM67370, GSM67371, GSM67372, GSM67373, GSM67374, GSM67375
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE3067
Gene Expression Omnibus
Dominant negative thyroid hormone receptor expression and PPARalpha activation effect on the heart
14
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