Interaction network and enrichment analysis of genes downregulated in SOCS3 KO
Canned Analysis
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General Information
AccessionDCA00038517
TitleInteraction network and enrichment analysis of genes downregulated in SOCS3 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between SOCS3 KO cells and control cells in the Macrophages stimulated for 100 minutes with IL-6 cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Ctsl|Rps11|Rps12|Gm16409|Gm13826|Gm12191|Ubb|Rpl23a|Rplp1|Rpl19|S100a4|Rpl34|Ppia|Rpl5|Rps19|Rps23|Fth1|Rpl7|Rps15a|Rplp0|Tyrobp|Hk1|Rsrp1|Gm15772|Gm10260
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorAliDot
CREEDS IDgene:2451
Cell TypeMacrophages stimulated for 100 minutes with IL-6
Gene Symbol (human)SOCS3
Gene Symbol (mouse)Socs3
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM6073, GSM6079, GSM6084
Perturbed SamplesGSM6076, GSM6082, GSM6087
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE411
Gene Expression Omnibus
Macrophage response to IL-6, and SOCS3 effect
14
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