Interaction network and enrichment analysis of genes downregulated in FOXO1 KO
Canned Analysis
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General Information
AccessionDCA00038587
TitleInteraction network and enrichment analysis of genes downregulated in FOXO1 KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between FOXO1 KO cells and control cells in the ventromedial hypothalamus cell type.
Analysis URLhttp://genemania.org/#/search/mouse/CYTB|Maged1|Snhg11|Tmem130|Ubg|Tuba1b|Eno2|Atp1b1|Ndn|Psap|Agrn|Plp1|Atp6v1b2|Rpn2|Ptplad1|Aatk|Mrps12|Prnp|Fbxo10|Tubb4b|Copg2os2|ATP6|Csrp1|Atp5b|Gprasp2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorcandicek
CREEDS IDgene:2493
Cell Typeventromedial hypothalamus
Gene Symbol (human)FOXO1
Gene Symbol (mouse)Foxo1
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM906960, GSM906961, GSM906962
Perturbed SamplesGSM906957, GSM906958, GSM906959
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE36948
Gene Expression Omnibus
Genome-wide analysis of transcription factor FoxO1-responsive gene expression in the ventromedial hypothalamus
7
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