Interaction network and enrichment analysis of genes downregulated in VHL KO
Canned Analysis
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General Information
AccessionDCA00038629
TitleInteraction network and enrichment analysis of genes downregulated in VHL KO
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between VHL KO cells and control cells in the Pancreatic islets cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Cela3a|Gm4076|Prss2|Try5|Cela2a|Rnase1|2210010C04Rik|Cpa1|Cel|Ctrb1|Pnlip|Cela3b|Ctrl|Pnliprp1|Clps|Zg16|Cpb1|Asah1|Sycn|Cela1|Slc2a2|Fos|Slc16a12|Gm10334|Pnliprp2
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis CuratorHollyWoodland
CREEDS IDgene:2527
Cell TypePancreatic islets
Gene Symbol (human)VHL
Gene Symbol (mouse)Vhl
Organismmouse
Perturbation TypeKO
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM289098, GSM289160, GSM289161
Perturbed SamplesGSM289162, GSM289163, GSM289164
Tools used in the analysis
Keyword
Dataset Accession
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
Datasets used in the analysis
Keyword
Tool Name
GSE11484
Gene Expression Omnibus
von Hippel-Lindau (VHL) tumor suppressor protein deficiency effect on pancreatic islet cells
7
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