Interaction network and enrichment analysis of genes downregulated in PLAGL2 OE
Canned Analysis
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General Information
AccessionDCA00038661
TitleInteraction network and enrichment analysis of genes downregulated in PLAGL2 OE
DescriptionThe analysis explores the gene interaction network and pathway enrichment of the top 50 most downregulated genes identified by applying the Characteristic Direction method comparing gene expression between PLAGL2 OE cells and control cells in the primary p53-null neural stem cells cell type.
Analysis URLhttp://genemania.org/#/search/mouse/Cst3|Mt2|Tmsb4x|Actg1|Eef1a1|Actb|Gfap|Pebp1|Fabp7|Capns1|LOC100048117|Cd81|Kxd1|Fos|Rhob|Lxn|Atp1b2|Ldha|Sparcl1|Eno1b|Sepp1|Serpine2|Rpl17-ps10|Rps23|Gapdh
Upload DateSeptember 20, 2017
Uploadermaayanlab
Metadata
Analysis Curatorstevann
CREEDS IDgene:2546
Cell Typeprimary p53-null neural stem cells
Gene Symbol (human)PLAGL2
Gene Symbol (mouse)Plagl2
Organismmouse
Perturbation TypeOE
Characteristic Direction parameters
Gene Setdownregulated
Gene Set Size50
Control SamplesGSM529445, GSM529449, GSM529451
Perturbed SamplesGSM529448, GSM529450, GSM529452
Tools used in the analysis
Keyword
Dataset Accession
Characteristic Direction
Published March 2014
A geometrical multivariate approach to identify differentially expressed genes
26829
GeneMANIA
Published June 2010
Biological network integration for gene prioritization and predicting gene function
7435
Datasets used in the analysis
Keyword
Tool Name
GSE21143
Gene Expression Omnibus
Zinc finger transcription factor PLAGL2 effect on primary p53-null neural stem cells
7
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